Angong Niuhuang Wan, which is from "Treatise on Differentiation and Treatment of Epidemic Febrile Diseases" written by Wu Tang in the Qing Dynasty, is consist of Calculus Bovis, Cornu Rhinocorotics, Moschus, Margarita , Cinnabaris, Realgar, Rhizoma Coptidis, Radix Scutellariae, Fructus Gardeniae, Radix Curcumae, Borneolum Syntheticum.
Angong Niuhuang Wan can cure various acute cerebrovascular diseases with good effectiveness and light after-effect, which is the main Chinese patent medicine of treating pyrexia with delirium and stroke. But because the components of Cinnabaris and Realgar include HgS and As2s2, the concentration of mercury and arsenic get above the standard, which is critical affect the clinical application and export of Angong Niuhuang Wan. Cerebrovascular disease is common disease of nervous system, which morbidity, mortality and disability is high. The important pathological base of stroke is cerebral edema and hernia, which can cause a series of biochemical disturbance, such as energy equilibrium, electrolyte balance, enzyme system function, oxygen free radical and nerve transmitter content and function disturbance and so on. Traditional Chinese Medicine take the view that the cause of stroke is deficiency of liver-yin and kidney-yin, and the symptoms of stroke is consist in wind, fire, phlegm and breathe, which can influence each other in the course of stroke. So Angong Niuhuang Wan can remove heat from the heart to resuscitate and protect brain tissues in order to awake the patients.
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Wang YH.
Consciousness-restoring effect of angong niuhuang pills in craniopathy
Zhong Xi Yi Jie He Za Zhi
104 patients of craniopathy with unconsciousness were treated with Angong-Niuhuang Pills (ANP) for a prospective random study. In 104 patients of Group A, ANP seemed to be an efficient drug to 79 patients (76%). 13 of them were on the mend with degree I consciousness. 4, 23, 24, 10 and 5 of the patients with degree II, III, IV, V and VI consciousness respectively. 25 patients failed to respond to medical treatment (24%). In 104 patients of Group B without ANP treatment, only 43 patients responded to other medical treatment (41%). 8, 4, 18, 9, and 4 patients took a turn for the better and got degree I, II, III, IV and V consciousness respectively. Inefficiency was observed among 61 patients (59%). Thus, there was a significant difference between the two groups statistically (P less than 0.005). Effects of Cinnabar and Realgar in Angong Niuhuang powder on heat shock protein, nitric oxide synthase and inflammatory cytokines in contusion cerebral edema
Effect of angong niuhuang pill as an adjuvant treatment on moderate or severe neonatal hypoxic-ischemic Encephalopathy
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