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Excess production of reactive oxygen species (ROS) of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes (Jinkui Shenqi Wan). TCM holds that the damp from the dysfunction of spleen, kidney and liver is the causative factor of complications of diabetes. This is similar to the mechanism of ROS resulting in angiopathic complications of diabetes. When the angiopathic complications of type II diabetes mellitus (T2DM) are differentiated as caused by turbid damp in TCM can be explained as ROS. Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis, the treating principle should be dissolving the damp to remove the obstruction. Jinkui Shenqi Wan Objective
To discover the effect of the total flavones from Semen cuscutae (TFSC) on the kidney-yang deficiency male mouse, especially on hormone levels and the androgen receptor (AR) mRNA and protein level in the kidney and testicle - Jinkui Shenqi Wan.
ICR male mouse were separated into six groups, and, except for the normal group, hydrocortisone was injected intraperitoneally to make the kidney-yang deficiency - Jinkui Shenqi Wan. The groups were then treated with TFSC, methyltestosterone and Jinkui Shenqi Wan, except for the normal group and control group. 14 days after administering, testosterone levels in the total serum were analysed by radioimmunoassay, AR mRNA levels measured by real time RT-PCR and protein levels by immunohistochemistry.
The control group had the lowest testosterone level, AR mRNA level and protein level, and the TFSC can reverse the reduction of testosterone level, AR mRNA level and protein level induced by the hydrocortisone.
This is the first study to demonstrate that TFSC treatment may reverse kidney-yang deficiency symptoms by restoring the levels of testosterone and AR mRNA and protein expression in the kidney and testicle.
Keywords: Semen cuscutae; TFSC; Androgen receptor; Real time RT-PCR; Immunohistochemistry, Jinkui Shenqi Wan.